ea0012p121 | Steroids to include Cushing's | SFE2006
Lolli F
, Christ-Crain M
, Kola B
, Wittman G
, Fekete C
, Grossman AB
, Korbonits M
Cushings syndrome is characterized by a diverse set of clinical manifestations, including hypertension, apparent obesity and metabolic aberrations such as diabetes, dyslipidaemia, ultimately leading to the metabolic syndrome. AMP-activated protein kinase (AMPK) is an intracellular energy sensor. It integrates nutritional and hormonal signals by switching on catabolic pathways, such as fatty acid oxidation and glycolysis and switching off anabolic pathways, such as fatty ...